HK2 and head and neck squamous cell carcinoma: Interestingly, as shRNA-mediated HK2 manipulation seems to heterogeneously silence HK2 protein, HNSCC cells with greater HK2 loss (white arrows in Figure 3C) showed more and compacted F-actin staining signals compared with cells with less HK2 expression (yellow arrows in Figure 3C), revealing that HK2 loss potentially reduces F-actin level in a single-cell basis.