One interesting discovery from the current study is that in HNSCC cells HK2-mediated malignant suppression is likely through glycolytic manipulation based on the following data: (i) HK2 is highly expressed in HNSCC cells implying that HNSCCs are “glycolytic” tumor; (ii) HK2 inhibition triggers metabolic shift away from glycolysis toward mitochondrial metabolism and (iii) it is found that mitochondria are swelling and lack cristae in HNSCC cells compared with human oral fibroblasts (Supplementary Figure 5). This evidence concerns the gene HK2 and neoplasm.