HK2 and neoplasm: Numbers of molecular cues including signal transducer and activator of transcription 3 (32–35), protein kinase B (PKB), also known as Akt (19, 36–38), mammalian target of rapamycin (38–40), and PH domain leucine-rich repeat protein phosphatase (41), as well as autophagy (42, 43), have been found to control HK2-mediated metabolic alterations, thereby regulating tumor identity.