It has been shown that insufficient clearance of dysfunctional mitochondria, which can result from defective mitophagy, has been implicated in a series of pathophysiological conditions, including inflammasome activation, genotoxic stress, and promotion of tumorigenesis.[qv: 12,13] Another important finding is that loss of BRCA1 triggers inflammasome activation which then promotes Brca1 mutant tumor relapse and metastasis. Here, BRCA1 is linked to neoplasm.