BRCA1 and neoplasm: It is well known that most TAMs are considered to have an M2 phenotype, while playing a crucial role in building an immunosuppressive environment that blocks T cell activation.[qv: 36] The results show that more polarized M2 macrophages were recruited into Brca1 mutant tumor compared with those in WT MG and Trp53 mutant tumors (Figure 7H).