Mitochondria as dynamic organelles are constantly undergoing fission and fusion, which are essential for regulation of mitophagy.[qv: 10] Defects in mitophagy could lead to pathological conditions, such as neurodegeneration, inflammasome activation, and cancer.[qv: 11–13] Recent studies indicated that BRCA1 deficiency could impair oxidative phosphorylation and decrease ATP production in cardiac and muscle tissues,[qv: 14–16] suggesting that BRCA1 is involved in mitochondrial functions. Here, BRCA1 is linked to cancer.