Specifically, the proteins connexin 43 and protocadherin 7 permit the exchange of cGAMP via gap intersections between tumor cells and astrocytes, inducing IFN and NF‐κB signaling and consequently advancing brain metastasis.175 A study involving cGAS knockdown in cancerous cells brought about decreased phosphorylated IRF3 and IFN in co‐cultured astrocytes and is related to diminished metastasis in the brain.175. Here, IFNA1 is linked to neoplasm.