Several viruses can evade recognition by cGAS‐STING‐mediated immune pathways (Figure4).74 In viral infections of HSV and Vaccinia virus (VACV), as shown in mice, Mn2+ is released from Golgi and mitochondria into the cytosol and induces cGAS‐mediated IFN responses to DNA viruses. Here, CGAS is linked to viral infectious disease.