IFI16 is an exclusive host sensor protein associated in the EBV infection cycle evincing it a prospective therapy to fight EBV‐related infections, IFI16 expression in p16 therapy, Anti‐IFI16 IgG antibodies in infliximab (IFX) therapy, IFI16 in hepatocellular carcinoma (HCC) therapy. The gene discussed is IFI16; the disease is Epstein-Barr virus infection.