Systematically, STAG2 deficiency triggered spontaneous genomic DNA damage, active IFN‐stimulated gene (ISG) expression, and Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling via stimulation of the cGAS‐STING signaling pathway, which protected against viral infections, including rotaviruses (RVs).75 Here, STING1 is linked to viral infectious disease.