CGAS and cancer: Active immunity is essential in cellular processes, such as cellular senescence, cell death, and DNA damage repair, which are caused by genotoxic stress.116 Impaired genomic DNA, as a result of cancer‐causing agents, such as mitochondrial DNA leakage, etoposide, or radiation, 7,12‐dimethylbenz(a)anthracene (DMBA), and cisplatin, has been revealed as a fundamental cause of the cytosolic DNA in cancerous cells, which may trigger cGAS‐STING‐mediated immunity.42 The DCs take up DNA fragments, derived from damaged or cancerous cells, and activate the cGAS‐STING pathway.