TBK1 and autoimmune disease: In addition, aberrant detection of self‐nucleic acids, mainly double‐stranded deoxyribose nucleic acids (dsDNAs), can predict the outcome in devastating illnesses.4 Besides, the overactivation of this critical immune pathway contributes to the outcome in autoinflammation and autoimmune disease progression.5 cGAS‐STING‐mediated antiviral cellular response initiates downstream signaling pathways, which stimulate TANK binding kinase 1 [TBK1, an IKK (IκB kinase)‐related kinase].