NOD2 and neoplasm: The antitumor response of cGAS is triggered by tumor DNA in innate immunity, which promotes IFN induction, major histocompatibility (MHC) class I, and a co‐stimulatory cluster of differentiation (CD) molecules, such as CD86 and CD80.114 In cytotoxic T lymphocytes (CTL), CD3 T cell co‐receptor activates cytotoxic T‐cell (CD8+ naive T‐cells).