CGAS and neoplasm: Specifically, the proteins connexin 43 and protocadherin 7 permit the exchange of cGAMP via gap intersections between tumor cells and astrocytes, inducing IFN and NF‐κB signaling and consequently advancing brain metastasis.175 A study involving cGAS knockdown in cancerous cells brought about decreased phosphorylated IRF3 and IFN in co‐cultured astrocytes and is related to diminished metastasis in the brain.175