CGAS and Aicardi-Goutieres syndrome: It augments immunity by promoting the production of cytokines, including IFN‐β, IFN‐γ, and influencing DC activation, which stimulates cross‐priming of CD8+ T‐cells.118 Recently, excessive high‐dose radiation (20–30 Gy in 1 fraction) was demonstrated to disrupt tumor immunogenicity by prompting DNA exonuclease Trex1 to obstruct cGAS‐STING pathway induction.146 In autoimmunity of Aicardi‐Goutières syndrome, it has been exposed that RU.521 is dynamic and elective in cellular immune functionality of cGAS‐mediated immune signaling and decreases induction of IFN in macrophages in a mouse model.