NFKB1 and infectious disease: Sox2 triggers the transforming growth factor beta‐activated kinase 1 (TAK1) and its interacting partner TGF‐beta activated kinase 1 (MAP3K7) binding protein 2 (TAB2), thereby activating the transcription factor NF‐κB for innate immunity.1 These cytosolic sensors and their innate immune pathways have become an immunotherapy target for the treatment of infectious diseases (Figure2).28 Sensing microbial signatures triggers signaling pathways resulting in the initiation of transcription factors, comprising NF‐κB and IRFs, inducing the production of IFNs, including pro‐inflammatory cytokines.29