NICE advocates the utilisation of ODX testing in estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative, node-negative early breast cancer only if patients 'have an intermediate-risk of distant recurrence using a validated tool such as PREDICT or the NPI and the information provided by the ODX testing will inform adjuvant chemotherapy treatment decisions. This evidence concerns the gene ERBB2 and breast cancer.