After assessing the mRNA levels of ICAM1 and HELLS using the Oncomine online database (https://www.oncomine.org/resource/login.html) (Rhodes et al., 2004) (Figs. 7A and 7B), it was indicated that ICAM1 was down-regulated in lung cancer across five differet studies. The gene discussed is ICAM1; the disease is lung carcinoma.