Reduced expression of ICAM-1 could play a role in the suppression of tumor progression in many cancer cells, such as breast cancer (Ogawa et al., 1998), gastric cancer (Fujihara et al., 1999), lung cancer (Kotteas et al., 2014) and colorectal cancer (Maeda et al., 2002). The gene discussed is ICAM1; the disease is lung cancer.