PTH and osteoporosis: In another tooth extraction model, limited necrotic lesions in rats receiving ALN and DEX were rescued by PTH administration, which promoted overall tooth socket healing by increasing bone fill and connective tissue maturation.157,158 To date, recombinant human PTH (rPTH, teriparatide), a hormone known to affect both anabolic and catabolic functions of mineralized tissues, is the only FDA-approved anabolic agent for the treatment of osteoporosis.