TNFSF11 and osteoporosis: Some examples of drugs used to treat osteoporosis, osteopenia, genetic disorders of mineralized tissues, and cancer-mediated bone effects include alendronate (ALN), zoledronate (ZOL), and denosumab (DNB) (a RANKL inhibitor).3,4 Table 1 lists pharmaceutical agents including trade names associated with medication-related ONJ (MRONJ) and their primary use, oncologic or osteoporotic, based on their mode of action.