FBN2 and congenital contractural arachnodactyly: Cardiovascular features can be life-threatening and include mitral valve prolapse, mitral regurgitation, dilatation of the aortic root, and aortic regurgitation.86 Mutations in FBN2 are associated with the related disorder Congenital Contractural Arachnodactyly (CCA) (OMIM 121050).