Considering that TB in diabetic guinea pigs also resulted in an increased pro- and anti-inflammatory response in lungs, mediated by IFN-γ, IL-17A, IL-8, and IL-10 24, this unbalance in pro- and anti-inflammatory response detected in both models of TB-T2D may contribute to both a higher susceptibility to TB and a more severe disease43. Here, IFNG is linked to type 2 diabetes mellitus.