However, MEG3 expression is lost in several human tumors including osteosarcoma, hepatocellular cancer, gastric cancer, and non-small cell lung cancer (NSCLC) by promoter or intergenic differentially methylated region hypermethylation, suggesting that loss of MEG3 expression contributes to tumor development in several tissues106,107. This evidence concerns the gene MEG3 and osteosarcoma.