BCL2L1 and neoplasm: Functionally, let-7 acts as a tumor suppressor partially through the downregulation of several genes involved in cell death, as shown by the ectopic expression of let-7 resulting in the inhibition of BCL2L1 in colorectal cancer46 or by the induction of apoptosis via upregulation of BAK and BAX and downregulation of BCL-XL protein levels47.