Furthermore, IL-1β stimulation of NHEKs was found to induce upregulation of the mRNA and protein levels of pro-inflammatory cytokines, chemokines and antibiotic peptides including IL-36γ, CXCL1, CXCL2, CCL20, S100A7, S100A8 and S100A9, which are closely related to the pathogenesis of psoriasis. This evidence concerns the gene IL1B and psoriasis.