Over-expression of this protein has been found to promote apoptosis in a glioma cell line.28 MMP7 (matrix metallopeptidase 7) belongs to the matrix metalloproteinase family that are involved in the expansion and invasion of gliomas via extracellular matrix degradation.29,30 The methylation states of them are also well-predicted by morphometric features in the glioma samples. The gene discussed is MMP7; the disease is central nervous system cancer.