Much work has been done looking at MUC4 overexpression in pancreatic cancer, where the NIDO domain is thought to play a key role in metastases.67 Through its extracellular EGF‐like domain, MUC4 interacts with the receptor tyrosine kinase, ErbB2, and controls ErbB2 and ErbB3 tyrosine phosphorylation. Here, ERBB2 is linked to familial pancreatic carcinoma.