CDR2 and small cell lung carcinoma: Both our laboratory and that of Vedeleret al. have demonstrated that anti-Yo IgG can be taken up by Purkinje cells in rat cerebellar slice cultures and can cause cell death36–39; and anti-Hu IgG, associated with encephalomyelitis in the setting of small-cell lung cancer, has been shown to produce neuronal death in dispersed cultures of cerebellar neurons and of multiple neuronal populations in slice cultures of rat brains40,41.