CDR2 and encephalomyelitis: T lymphocyte response in patients with antibodies to internal cellular proteins (for example, Yo and Hu) has been repeatedly demonstrated: infiltrates of cytotoxic (CD8+) lymphocytes have been detected in brains of patients with encephalomyelitis and anti-Hu antibody26 and in cerebrospinal fluid (CSF) of a patient with anti-Yo–associated paraneoplastic cerebellar degeneration27.