Knockdown of FADD expression decreased TMZ induced PARP1 cleavage, activation of CASP8 and CASP3, and degradation of BCL2 and BCL-XL in ATRX knockout cells, indicating that suppression of FADD is responsible for ATRX mediated PARP1 stabilization and TMZ resistance in glioma cells. Here, CASP3 is linked to central nervous system cancer.