Knockdown of MYB and MYC resulted in myeloid differentiation whereas ectopic expression of these two genes restored the self-renewal properties of the leukemic stem cells (LSCs) in AML 114.The m6A reader protein YTHDF2 is also reported to increase the leukemic stem cells (LSCs) in AML. This evidence concerns the gene YTHDF2 and acute myeloid leukemia.