In RCHO-resistant DLBCL cells, BCR-mediated Syk, FAK, Src and FGFR1/2 signaling could activate PI3K/AKT1, which subsequently stabilized SOX2 by enhancing SOX2 phosphorylation and reducing SOX2 methylation. The gene discussed is FGFR1; the disease is diffuse large B-cell lymphoma.