Recently, the fatty acids such as punicic acid (PUA) was suggested as possible ligands of the C-terminal region of NLRX1, which includes LRR domain to inhibit NF-κB activation 42 and a chemical compound which is a activator of NLRX1, NX-13 was identified showing alleviated colitis by inhibition of Th1 and Th17 differentiation 43. The gene discussed is NFKB1; the disease is colitis.