Since NLRX1 deficient mice had more severe experimental autoimmune encephalomyelitis (EAE) than wild-type mice 31, and dNP2 showed remarkable protein delivery efficiency in T cells, we hypothesized that exogenous administration of NLRX1 proteins might be able to control EAE disease progression. Here, NLRX1 is linked to experimental autoimmune encephalomyelitis.