Related studies have shown that Ca2+/calmodulin-dependent protein kinase II (CAMKII), a multi-functional serine/threonine kinase, plays oncogenic roles in leukemia, lymphocyte and hepatocellular carcinoma through the mechanisms of stabilizing the level of classical oncoprotein c-Myc by inhibiting its ubiquitination degradation 16-18. Here, CAMK2G is linked to hepatocellular carcinoma.