Meanwhile, PD-1 antibody treatment inhibited the tumor growth, increased the survival time of mice, and resulted in an increased CD45+CD4+ and CD45+CD8+ T cell infiltration or decreased CD11b+Gr1+ myeloid cell infiltration in tumors compared to that in the control group (Figure 6E-6G) 24. The gene discussed is ITGAM; the disease is neoplasm.