Both T2DM models exhibited a DCM phenotype that featured cardiomyocyte hypertrophy, myocardial fibrosis, decreased microvessel density, and upregulated ANP and BNP expression; however, the obese T2DM mice exhibited more severe myocardial injury than did the non-obese T2DM mice. This evidence concerns the gene NPPB and type 2 diabetes mellitus.