The expression of the transcription factor NF-E2-related factor 2 (Nrf2) in the nucleus and its target genes heme oxygenase-1 (HO-1) and NAD(P)H:quinone oxidoreductase 1 (NQO1) at the 20th and 24th weeks of diabetes was significantly increased in the db/db mice compared with the db/m mice (Figure S5A and B). This evidence concerns the gene NFE2L2 and diabetes mellitus.