Correspondingly, the non-obese T2DM mice also exhibited the formation of cardiac remodeling, which featured upregulated ANP and BNP, overt cardiomyocyte hypertrophy, myocardial fibrosis, and decreased microvessel density at the 24th and 36th weeks of diabetes (Figure 2H-J). Here, NPPA is linked to Myocardial fibrosis.