In addition, both Bax expression and the cleaved-caspase-3/caspase-3 expression ratios were significantly increased in the hearts of the db/db mice and DM mice, whereas B-cell lymphoma-2 (Bcl-2) expression was significantly decreased in the hearts of both diabetic models (Figure S5A and B, Figure S6A and B). This evidence concerns the gene BCL2 and diabetes mellitus.