CD38 and neoplasm: Here, we compared the capacity of three CD38-specific hcAbs (WF211-hcAb, MU1067-hcAb, JK36-hcAb) that recognize three different epitopes of CD38 (E1, E2, E3) and of daratumumab (epitope E1) to induce CDC and ADCC in CD38-expressing tumor cell lines in vitro and in patient MM cells ex vivo as well as effects on xenograft tumor growth and survival in vivo.