PAK5 and Familial prostate cancer: In order to gain mechanistic insight into the function of mitochondrial PAK6 in prostate cancer cells, based on the previous study of the investigators, which revealed that PAK5-mediated GATA1 phosphorylation is linked to histone deacetylation in E-cadherin transcription regulation, it was speculated that class II PAKs are closely correlated to the deacetylase family 45.