For example, circAKT3 could up-regulate PIK3R1 through adsorbing miR-198, and then enhance cisplatin resistance in gastric cancer 26; circPAN3 sponge miR-153-5p/miR-183-5p to mediate the doxorubicin chemoresistance in acute myeloid leukemia 27. Here, PIK3R1 is linked to gastric cancer.