Three trials reported the effect of CKI plus PBC on 1-year survival rate 62, 72, 76 and the result of meta-analysis showed that, compared with PBC alone, CKI plus PBC significantly increased 1-year survival rate (RR = 1.51, 95% CI 1.18 to 1.94, P = 0.001; Figure 7). Here, CHKA is linked to primary biliary cholangitis.