Many studies have shown that CKI and its active ingredients have notable anti-tumor activities 17, 18, 19, such as inhibiting cancer cell proliferation, invasion and metastasis 16, 20, 21, inducing tumor cell apoptosis 22, 23, reducing angiogenesis 21, inducing cell cycle arrest 20, 21, 23, inhibiting glycometabolism and amino acid metabolism 16, and reversing multidrug resistance 24, 25. Here, CHKA is linked to neoplasm.