Specifically, ORC1 had amplification more than 12% in HCC and intrahepatic cholangiocarcinoma (ICC) and mutation less than 2% HCCs (Figure 8A); ORC2 had amplification more than 1% and mutation less than 1% (Figure 8B); ORC3 had amplification, mutation and deep deletion more than 2.5% together (Figure 8C); ORC4 had mutation and deep deletion more than 1.5% together (Figure 8D); ORC5 had mutation and amplification more than 1% together (Figure 8E); ORC6 had amplification and deep deletion more than 1.5% together (Figure 8F). The gene discussed is ORC3; the disease is hepatocellular carcinoma.