Aside targeting cellular cytokines, EBV miRNAs inhibit the destruction of B cell and epithelia cell derived cancers by down-regulating expression of tumor suppressor genes; miR-BHRF1-2 has been reported to silence the expression of PRDM1/Blimp1which is a tumor suppressor in B cells, hence promoting lymphogenesis 96. The gene discussed is PRDM1; the disease is neoplasm.