Since ER and PR played pivotal roles in the development and progression of LABC 23, meanwhile FKBP4 chaperonin HSP90 promoted tumor progression by enhancing various oncogenes 24, more researches are warranted to find out whether FKBP4 influences the ER or PR status via HSP90 or they perform collectively toward the prognosis in the BC setting. The gene discussed is HSP90AB1; the disease is breast cancer.