The expression of RIPK4 was correlated with worse DFS for ccRCC patients, as well as CDC42 (HR=0.68, log-rank P=0.033), PTPN11 (HR=0.65, log-rank P=0.021), KITLG (HR=0.56, log-rank P=0.002), IGF1R (HR=0.48, log-rank P=7.8e-05), SERPINE (HR=1.7, log-rank P=0.0065), AURKB (HR=2, log-rank P=0.00029), GNA13 (HR=0.68, log-rank P=0.04), DLG2 (HR=0.48, log-rank P=7.9e-05), ACTN2 (HR=2.2, log-rank P=2.3e-05) (Figure 4a-j). The gene discussed is ACTN2; the disease is nonpapillary renal cell carcinoma.