Then, we chose RIPK4, CDC42, PTPN11, KITLG, IGF1R, AURKB, GNA13, DLG2 and ACTN2, which was associated with both OS and DFS, to evaluate the expression level between ccRCC and normal tissue using TCGA database. This evidence concerns the gene PTPN11 and nonpapillary renal cell carcinoma.