Univariate and multivariate logistic regression analyses (Table 2) revealed that creatinine corrected total BLCA-4 (P<0.001), BTA (P<0.001), NMP22 (P<0.001), CEA (P=0.002) concentrations, body mass index (P=0.007), smoking (P<0.001), family history of bladder cancer (P<0.001), occupational exposure to aromatic amine chemicals (P<0.001), number of tumours (P=0.010), and bladder instillation of chemotherapeutic agents (P<0.001) had significant influence on recurrence. The gene discussed is NUMA1; the disease is urinary bladder cancer.