According to the prediction of KEGG (Kyoto Encyclopedia of Genes and Genomes) bioinformatics database, we detected the alteration of the PI3K/AKT signaling pathway downstream proteins MMP9 and TP53, which were closely related with preeclampsia (Gao et al., 2016; Chen and Khalil, 2017), after GAS5 expression changed. Here, TP53 is linked to preeclampsia.