TP53 and cancer: The 10 most significantly enriched IPA pathways included: “Molecular Mechanisms of Cancer,” “p53 Signaling,” “HGF Signaling,” “Glucocorticoid Receptor Signaling,” “Pancreatic Adenocarcinoma Signaling,” “ERK/MAPK Signaling,” etc. Previous studies found that some of signaling pathways involved in the bone cell differentiation and apoptosis processes that affect bone metabolism and BMD.