BCL2 and schizophrenia: Notably, all three schizophrenia-implicated networks regulated by miRNA included BCL2, a well-known regulator of apoptosis and mitochondrial dynamics, and a calcium voltage-gated channel subunit alpha1 C (CACNA1C), one of the L-type calcium channels (LTCCs) defining the calcium influx into cells, and these are critical for normal brain development and plasticity (Figure 1).