THOC2 and neurodevelopmental disorder: The proximal breakpoint of the Xq deletion according to array-CGH resides on THOC2, a gene subject to XCI that was previously associated to neurodevelopmental disorders in males (Kumar et al., 2015) and also in a female with a de novo missense variant (p.Tyr517Cys) and no available XCI status data (Kumar et al., 2018).