Consistent with the studies on trypanosomiasis described below (section Psychiatric Disorders), in which kynurenine levels were positively correlated with IL-10, down-regulation of IDO1 in the atherosclerosis model resulted in a diminished expression of IL-10 in most lymphoid tissues including peripheral blood, spleen and lymph node B cells (69). The gene discussed is IDO1; the disease is atherosclerosis.