For instance, it has been reported (34) that macrophages in the TNBC have a supportive role for tumor growth by the following mechanisms: (1) production of anti-inflammatory cytokines and other factors; (2) inhibition of T cell functions in the tumor microenvironment; (3) induction of regulatory T cell differentiation; and (4) upregulation of immune checkpoints like PD-1. The gene discussed is PDCD1; the disease is neoplasm.