To investigate the specific role of JAK1-mediated signaling in CLE, phosphorylated JAK1 (pJAK1) expression in lesional skin [Subacute cutaneous lupus erythematosus (SCLE, n = 5) and chronic discoid lupus erythematosus (CDLE, n = 5) subsets] was compared to lichen planus (LP, n = 6), another inflammatory skin disorder, as well as healthy controls (HC, n = 5). This evidence concerns the gene JAK1 and inflammatory skin disease.