CCL3 and Splenomegaly: Here, splenomegaly was similarly detected in ccl3+/+ (3.29 ± 0.31 mg/g in NI vs. 9.68 ± 0.58 mg/g in infected ccl3+/+ mice; p < 0.001) and ccl3−/− (3.78 ± 0.17 mg/g in NI vs. 8.93 ± 0.49 mg/g in infected ccl3−/− mice; p < 0.001) T. cruzi-infected mice.