APP and Alzheimer disease: We have previously shown that the food burrowing task is the most sensitive test to assess early behavioral perturbations in hTau mice bred on either an mTau−/− (49) or mTau+/− (48) background, and that this behavior is suppressed 4 h after inoculation with LPS in an APP/PS1 mouse model of AD and their Wt littermates (57).