Given that BAFF is a key cytokine for GC maintenance in mice (31, 32) but its excess favors autoimmunity (46, 47), we hypothesized that blockade of the BAFF excess reported during the acute phase of SIV infection (40) might “reset” the GC reaction and initiate a more effective virus-specific response. The gene discussed is TNFSF13B; the disease is Autoimmunity.