HLA-A and metastatic colorectal cancer: Lo et al. screened tumor-infiltrating lymphocytes for the recognition of mutated neoantigens in a patient with metastatic colorectal cancer in a HLA-A-dependent manner; they found that the minimal peptide epitope of pR175H was HMTEVVRHC, and the screened TIL also mediated the recognition of p53 pR175H+ colon, breast, and leukemia cell lines after transduction with a retrovirus encoding HLA-A*0201 (76).