The role of CCL-3 as a potential biomarker of white matter inflammation and disease course in early RRMS phases (i.e., when the inflammatory component of MS is particularly relevant) stimulates further investigation, especially in comparison/association with other putative prognostic biomarkers, such as Neurofilaments Light (NFL) (41) and Chitinase 3-like 1 (42, 43). Here, NEFL is linked to myeloid sarcoma.