Through the examination of thousands of individual peripheral blood mononuclear cells (PBMCs), derived from six dengue patients and four healthy controls, multiple interferon (IFN)-response genes, particularly MX2 in naive B cells and CD163 in CD14+, CD16+ monocytes, were found to be upregulated in a cell-specific manner before progression to severe dengue (Zanini et al., 2018). The gene discussed is IFNA1; the disease is dengue disease.