APLNR and ischemic stroke: Hata et al. reported that rs9943582, a single-nucleotide polymorphism (SNP) which is located in the promoter region of the APJ gene and can enhance the expression level of APJ mRNA, could increase the risk of ischemic stroke in Japanese, and that the risk of ischemic stroke in the GG genotype was significantly higher than other genotypes (97–99).