For example, metformin, a first-line drug prescribed for T2D management derived from the medicinal plant Galega officinalis L. (Fabaceae) (French lilac or Goat’s rue) (Bailey, 2017), can decrease hepatic gluconeogenesis flux by reducing the gene expression of G6Pase and phosphoenolpyruvate carboxykinase (PEPCK), and promoting allosteric inhibition of fructose-1,6-bisphosphatase (F-1,6-Pase) (Hardie, 2013; Viollet and Foretz, 2013; Foretz et al., 2014; Tan et al., 2016; Hunter et al., 2018). Here, G6PC1 is linked to type 2 diabetes mellitus.