A study by Fattahi et al. (2018b) has shown that LVEF was increased and plasma pro-inflammatory cytokines (TNF-α, IL-1, IL-6) were decreased significantly in a mouse septic model with TLR9 and TLR3 deletion, suggesting that TLR9 and TLR3 activation is associated with dysfunction of heart in sepsis. The gene discussed is TLR9; the disease is Sepsis.