Similar to the anti-apoptotic effects of GM15645, lncRNA Taurine upregulated-1 (TUG-1), was downregulated in the DN and hyperglycemic condition, with evidence of renal damage and loss of podocyte cells in DN patients and animal model (Lei et al., 2018; Shen et al., 2019). This evidence concerns the gene TUG1 and liver dysplastic nodule.