In terms of inflammation, miR-27a is a pro-inflammatory miRNA that negatively regulates the expression of nuclear factor erythroid 2-like 2 (NRF2) and peroxisome proliferator-activated receptor γ (PPARG), thus promotes the secretion of pro-inflammatory cytokines in DN animal and cell line models (Hou et al., 2016; Song et al., 2018; Zhou et al., 2018). Here, NFE2L2 is linked to liver dysplastic nodule.