This NEAT1-mediated ECM suppression was due to its interaction with miR-27b-3p, and its target, the TGFB inducer, Zeb1, in which NEAT1 is no longer suppressing the miR-27b-3p, which in turns activates the suppression of Zeb1, and thus can prevent DN progression (Wang et al., 2018d). The gene discussed is ZEB1; the disease is liver dysplastic nodule.