The presence of TGFB in the kidney usually indicates a progression towards the renal hypertrophy and extracellular matrix (ECM) accumulation, together with evidence of RAS activation during renal hypertension Recent findings in DN patients and animal models have revealed that some of these ncRNAs regulate these early events in DN development (Bhat et al., 2016; Leti and DiStefano, 2017). The gene discussed is TGFB1; the disease is liver dysplastic nodule.