Similar to SIRT1, Sirtuin-7 (SIRT7) expression is also important to prevent podocyte cells apoptosis, and low SIRT7 expression in hyperglycemic podocyte cells and DN mice, was due to being negatively regulated by miR-20b (Wang et al., 2017) Besides that, the miR-30 family members are also anti-fibrotic miRNAs, in which their expressions are reduced in DN patients (Eissa et al., 2016b). This evidence concerns the gene SIRT1 and liver dysplastic nodule.