NLRP3 inflammasome complex, implicated in the progression of NAFLD from NAFL to NASH, contains NOD-like receptor pyrin domain containing 3 (NLRP3), a speck-like protein and damage-associated adaptor molecule with a caspase recruitment domain (ASC) and procaspase-1 as its effector molecule (He K. et al., 2017). The gene discussed is NLRP3; the disease is metabolic dysfunction-associated steatotic liver disease.