Thus, the development of fatty liver disease in mice deficient in NLRP3 (Nlrp3−/−) or its essential components (Asc−/− and Casp1−/− mice) can be avoided if they consume a high fat or nutrient-deficient diet (Dixon et al., 2012; Wree et al., 2014b). Here, CASP1 is linked to fatty liver disease.