EGF and neoplasm: We used A431 cell line for the other experiments, since the results for the previously described MNTC-EGF were obtained on this cell line (Gilyazova et al., 2006; Rosenkranz et al., 2008; Slastnikova et al., 2012a; Koumarianou et al., 2014; Slastnikova et al., 2017b; Rosenkranz et al., 2018), however for A431 activation of EGFR leads to inhibition of the tumor cell proliferation (Kawamoto et al., 1983; Bromberg et al., 1998).