ESR1 and rheumatoid arthritis: Furthermore, several randomized controlled trial about the efficacy of Gui-Zhi-Shao-Yao-Zhi-Mu-Tang with WM showed that after taking Gui-Zhi-Shao-Yao-Zhi-Mu-Tang with WM for 4-12 weeks, there was a significant decrease in ESR, RA factor, and CRP (Daily et al., 2017).