Endothelial dysfunction has been demonstrated in most animal models of hypertension including spontaneously hypertensive rats (SHRs), angiotensin II-induced hypertension, Dahl salt-sensitive rats, and the two-kidney one-clip model (Stankevicius et al., 2002; Yang et al., 2004; Michel et al., 2008). Here, AGT is linked to Hypertension.